ORANGE HealthHoorn Study
Characteristic | Description
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Name of the cohort | The Hoorn Study |
Description / aim of the cohort | The Hoorn study studies the course of development and progression of Diabetes. The Hoorn study aims to determine the psychological, social, biological and genetic factors that influence the development and progression of Diabetes. The Hoorn study consists of three waves, one started in 1989, one in 2007 and one in 2024. We have data on oral health in wave 2, the information from now on is on wave 2 of the Hoorn studies only.
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Description of the cohort population (age, specific characteristics, e.g. adults with cardiovascular disease, low SEP) | Adults from the general population, aged 40-65 years at baseline
Cohort profile:
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Location of the cohort | Region West Friesland
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Institution | Amsterdam UMC
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Cohort size (n) | 2807 participants
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Start year of the cohort | 2006
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Follow-up (years and n) | 4 times over the past 19 years: - 2006-2007 (n=2807) - 2010-2011 (subgroup) (n=206) - 2013-2015 (n=1734) - 2021-2025 (n=963)
The whole group is still being followed for mortality and morbidity through GP and hospital registrations and registry (ie. CBS).
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Types of variables (e.g., health behaviours, psychosocial factors, clinical health outcomes, demographic characteristics) Measurement methods (e.g., questionnaires, clinical assessments, biosamples) | General demographics Age and sex Education level Family history Diabetes Smoking status Weight, Height and BMI Neck, waist and hip circumference Handgrip strength Blood pressure Medication use Medical history Cognitive test (MoCA)
Diabetes-related markers from blood Fasting glucose and HbA1c levels 2h glucose levels after OGTT
Other biomarkers from blood Cholesterol and Triglycerides levels Vitamin D Estimated Glomerular Filtration Rate (eGFR)
We have an extensive biobank, containing samples on plasma, serum and urine.
Physical tests (only in 2010-2011 subgroup) Electrocardiogram (ECG) Pulse wave velocity Intima-media thickness (IMT) Body fat distribution by DXA
Urine test Blood Proteins Nitrite Ketones Glucose pH SG Leukocytes
Genetics DNA isolated
Questionnaires Physical activity, hours per day Food Frequency Questionnaire Cardiovascular disease via Rose Depressive symptoms via CES-D Stressful life events Health survey via SF36 Depression and anxiety via HADS Disease specific complaints Burnout Mastery Personality via BIG5 Resilience via BRSnl Optimism and pessimism via LOT-R10 Anger and emotional support Eating behaviour via TFEQ Time-restricted eating (TRE) Eating habits Reward sensitivity to food via PFS Attitude, norms and beliefs towards lifestyle behaviour via Ciberlite Objective and subjective environment Health literacy Sleeping behaviour Sleep apnea (OSA) Quality of Life Life vision Work-life balance |
Oral health variables (questionnaire/self-reported) | 2013-2015: Own teeth Bleeding gums Periodontitis diagnosis Number of loose/fallen out teeth
2021-2025: Self-rated oral health Self-reported number of teeth (Partial) dentures Oral symptoms (toothache, bleeding gums, dry mouth) Dental visits Reasons for (no) dental visits Treated for periodontitis Toothbrushing frequency
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Oral health variables (clinically assessed)
| NA |
Oral health variables (biological, e.g., microbiome data, saliva)
| NA |
Reference to design paper |
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Website | |
Procedure for requesting data | Data request form: https://hoornstudies.com/data-request-form/
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Procedure for data storage | A data transfer agreement will be put into place and data is only shared anonymized.
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Associated costs for data requests (yes/no) | Depending on the type of collaboration, costs for data issue might be in place.
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Contact person / principal investigator |
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